Anadrol reviews hydrochloride 240 mg per tablet. Excipients: sodium alginate, microcrystalline cellulose, povidone, magnesium stearate. Coating: Opadry clear YS-1-7006 (6sR hypromellose, Macrogol (PEG 400), macrogol (PEG 8000) ); Opadry Yellow YS-5-12577 (ZSR hypromellose, hydroxypropyl cellulose (giproloza), titanium dioxide, macrogol (PEG 400), hypromellose 50sR, dye yellow varnish).

Description: Elongated oblong biconvex film-coated tablets of white color with a yellowish shade, with dividing Valium and marked on one side of the tablet: 73 (on one side of the risks) and 00 (on the other side of the risks) and two triangles facing each another tablet on the other side.

 

Pharmacotherapeutic group:

blocker “slow” calcium channels.

 

Pharmacological properties Pharmacodynamics Blocker “slow” calcium channels inhibits the transmembrane transport of calcium ions to the contractile fibers of smooth muscle cells. Antianginal effect is due to a direct effect on the myocardium and the effect on peripheral hemodynamics, by lowering the tone of the peripheral arteries and total peripheral vascular resistance. Incoming blockade of calcium ions into the cell leads to a reduction of myocardial contractility, decrease in myocardial oxygen demand. anadrol reviews has antispasmodic, hypotensive action and negative chronotropic action ino significantly reduces conduction through the atrioventricular node prolongs the refractory period, sinus node automaticity suppressed. Pharmacokinetics When administered anadrol reviews about 90% absorbed in the gastrointestinal tract, but low bioavailability and It is approximately 20% due to the intensive first-pass metabolism in the liver. Contact with blood plasma proteins – 90%. The maximum concentration of 80-400 ng / ml. Time of onset of the maximum concentration in plasma in case of prolonged forms is 5-7 hours. The half-life for prolonged forms 11 hours. The anadrol reviews mainly excreted by the kidneys and about 25% of bile. The drug crosses the placental barrier.Provided with breast milk. anadrol reviews is rapidly metabolized in the liver by N-dealkylation and O-demethylation to form several metabolites. The accumulation of the drug and its metabolites explains the strengthening of actions at course treatment. The most important metabolite noranadrol reviews pharmacologically active.Development of tolerance to the anadrol reviews is not observed.

Indications

  • Arterial hypertension
  • Prevention of angina attacks (including Prinzmetal variant angina)
  • Prevention nadzheluchkovyh tachyarrhythmias

 

Contraindications

  • Hypersensitivity to the drug
  • Severe bradycardia
  • hypotension
  • Cardiogenic shock
  • The acute phase of myocardial infarction complicated (with symptoms of bradycardia, marked hypotension, left ventricular failure)
  • Aortic stenosis
  • The syndrome of Morgagni-Adams-Stokes
  • Atrioventricular (AV) block degree II-III
  • sinoatrial block
  • Syndrome WPW (Wolff-Parkinson-White syndrome)
  • sick sinus syndrome (bradycardia-tachycardia syndrome)
  • digitalis intoxication
  • Intravenous administration of beta-blockers within the last 2 hours
  • Pregnancy and lactation
  • Age 18 years (effectiveness and safety have been established)

With care prescribe a drug to patients with impaired liver function with AV blockade degree I, chronic heart failure, arterial hypotension (systolic blood pressure less than 90 mmHg), flickering / atrial flutter with WPW syndrome (risk of ventricular tachycardia).

 

Dosing and Administration
VEROGALID EP 240 should be taken during meals with a little water. Tablets do not chew. Doses picked individually. High blood pressure in patients with hypertension drug dose ranges from 240 mg to 360 mg. The maximum daily dose of 360 mg. The increase in the daily dose to 480 mg should be carried out only in a hospital! Usually VEROGALID EP 240 administered in an average daily dose of 240 mg (1 tablet) once daily in the morning, if necessary to 240 mg in the morning and 120 mg (½ tablet ) evening with an interval of 12 hours. Lower initial doses of 120 mg administered to patients with impaired hepatic and renal function, elderly patients. Prophylaxis of angina attacks at the beginning of the treatment drug is prescribed 120 mg of multiplicity 1 reception – 2 times a day with an interval of 12 hours.The maximum daily dose of 240 mg. Prophylaxis of supraventricular tachyarrhythmias average single dose of 120 mg with a multiplicity of reception 1-2 times a day.

Side effect On the part of the cardiovascular system: sinus bradycardia, sinoatrial block, asystole, AV block I, II and III degree, bradiaritmicheskaya atrial fibrillation, hypotension, heart failure, decreased blood pressure, palpitations, tachycardia. From the nervous system: rare – dizziness, confusion, headache, drowsiness, fatigue, irritability, paresthesia. On the part of the gastrointestinal tract: constipation, nausea, vomiting, intestinal obstruction, pain or discomfort in the abdomen. Laboratory indicators: increase in “liver” transaminases, alkaline phosphatase. . Other: allergic reactions (rash, urticaria, angioedema, Stevens-Johnson syndrome), flushing, peripheral edema, very rarely – myalgia and arthralgia were reported cases of galactorrhea and impotence; gynecomastia, hyperplasia of the gums, which are reversible and disappear after discontinuation of therapy. Rare: angina, until the development of myocardial infarction (particularly in patients with severe obstructive coronary artery disease); fainting, anxiety, fatigue, depression, extrapyramidal disorders; nausea, rarely – diarrhea; weight gain, very rarely granulocytosis.

Overdose Symptoms: bradycardia, AV block, marked reduction in blood pressure, heart failure, shock, asystole, sinoatrial block. Treatment: when detected early – gastric lavage is recommended in all cases, if after taking the drug have passed at least 12 hours, as well as a later date at a reduced GI motility (no bowel sounds on auscultation). Treatment is symptomatic. In violation of rhythm and conduction – in / isoprenaline, norepinephrine, atropine, 10-20 ml of a 10% solution of calcium gluconate, artificial pacemaker; I / plasma-infusion solutions. Hemodialysis is not effective. In order to increase the pressure in patients with hypertrophic obstructive cardiomyopathy not be used isoprenaline and norepinephrine.

Interaction with other drugs

When concomitant administration of the drug VEROGALID EP 240 with carbamazepine, there is a strengthening of the last, and increases the risk of toxic lesions of the nervous system.
Appointment VEROGALIDa EP 240 patients receiving long-term lithium medication, may reduce the concentration of lithium in blood serum.
Simultaneous application with phenobarbital or rifampicin reduces efficiency VEROGALIDa 240. EP
cimetidine enhances the effect of EP 240 VEROGALIDa as anadrol reviews increases bioavailability by almost 40-50% (by ​​reducing hepatic metabolism), in connection with which it may be necessary to reduce the dose of the latter.
Nicotine, speeding up the metabolism in the liver, leading to a decrease in the concentration of anadrol reviews in the blood, which leads to a decrease in the severity of antianginal, hypotensive and antiarrhythmic action.
while the use of inhaled anesthetics increase the risk of bradycardia, AV block, heart failure.
Interactions with other antihypertensive drugs It leads to mutual reinforcement of their activities. Combination with beta-blockers may result in potentiation of negative inotropic effect, increasing the risk of violations of AV conduction, bradycardia.
At the same time taking the drug VEROGALID EP 240 and digoxin, theophylline, cyclosporine or quinidine, may increase blood concentrations of the above-mentioned drugs on the background of anadrol reviews therapy.
With glipoglikemicheskimi agents: atorvastatin (increased serum levels of atorvastatin), lovastatin (increased serum levels of lovastatin), simvastatin (increase in AUC of approximately 2.6-fold and the maximum concentration of about 4.6 times simvastatin). Patients receiving anadrol reviews treatment of HMG-CoA reductase inhibitor should be possible to start with low doses which are gradually increased. If you want to assign anadrol reviews to patients already receiving HMG-CoA reductase, it is necessary to review their dose, respectively, the concentration of cholesterol in the blood serum.
Fluvastatin, pravastatin and rosuvastatin are not metabolized by the action of isoenzymes of CYP3A4, poetouu their cooperation less likely.
With almotriptanom – increase in AUC of approximately 20% and the maximum concentration of almotriptan approximately 24%).
Grapefruit juice -. increase in AUC and maximum concentration of anadrol reviews
St. John’s wort – reduced AUC anadrol reviews with a corresponding reduction in the maximum concentration.
doxorubicin – decreases the half-life of doxorubicin (approximately 27%) and maximum concentration (approximately 38%).
In patients with progressive tumors anadrol reviews not affect the clearance rate or doxorubicin. In patients with small cell lung cancer, anadrol reviews reduces the half-life and the maximum concentration of doxorubicin.
Hypoglycemic agent (Glyburide) – glyburide increase the maximum concentration (approximately 28%), AUC (approximately 26%).
Aspirin (acetylsalicylic acid) – increased bleeding.

Cautions
Heart failure is necessary prior to administration of anadrol reviews pre-compensate.
In order to increase blood pressure in patients with hypertrophic cardiomyopathy prescribe alpha-agonists (phenylephrine) should not be used zoproterenol and epinephrine. Do not stop treatment abruptly.
When treatment is necessary to control the function of the cardiovascular and respiratory systems, the level of sugar and electrolytes in the blood, blood volume and urine output. The use in pregnant and lactating women is shown only in those cases where the expected benefit to the mother exceeds the possible negative effects on the fetus or child.

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