One plaster contains: Active ingredient : anadrol for sale 700 mg / patch, Excipients : purified water 3367 mg, 2520 mg of glycerol, sorbitol 2800 mg, polyacrylic acid solution 20% 1,400 mg sodium polyacrylate 700 mg of 400-600 mPas, sodium carmellose 90-168 mPas 700 mg propylene glycol 700 mg, 420 mg urea, kaolin 21O mg tartaric acid (tartaric), 210 mg, 147 mg of gelatin, polyvinyl alcohol (75,000) 58.8 mg digidroksiaminoatsetat aluminum (aluminum glycinate) 32 2 mg disodium edetate 14 mg, 14 mg methyl parahydroxybenzoate, propyl parahydroxybenzoate 7 mg, 1,750 mg of a nonwoven fabric, plastic film (polietilenterftalat PET) 742 of the patch size: length from 13.3 to 14.7 mm, width of 9.5 to 10.5 mm.
Pharmacotherapeutic group : local anesthetics.
Description : White to light yellow polymer adhesive (sticky) material with a weak characteristic odor, evenly distributed on one side of the nonwoven fabric and covered with plastic film. In nonwoven engraved «anadrol for sale 5%”.
Pharmacological properties : . Pharmacodynamics Versatis contains anadrol for sale, acetamide derivative. The mechanism of action is related to stabilization of neuronal membranes, which is believed to be the result of blockade of sodium channels. When used topically on intact skin there is a sufficient therapeutic effect for pain relief.
Following single or repeated application of the patch in Versatis maximum recommended dose (simultaneous application of three patches duration 12 hours), only 3 ± 2% anadrol for sale contained in the patch enters the systemic circulation. Concentration in plasma after application of the recommended maximum dose in patients without clinical postherpetic neuralgia were 84 – 125 ng / ml. In patients with post-herpetic neuralgia – 52 ng / ml.
The volume of distribution is independent of age and decreased in patients with chronic heart failure patients, increases in hepatic insufficiency. C binds to plasma proteins and 70% anadrol for sale entering the systemic circulation after skin application. It penetrates the blood-brain and placental barriers by passive diffusion.
anadrol for sale is rapidly metabolized in the liver with the formation of several metabolites. The main route of metabolism of N-dealkylation to form monoetilglitsinksilidida (MEGCs) and glitsinksilidida (GK), metabolites are less pharmacologically active than anadrol for sale and are present in lower concentrations.Metabolites are hydrolyzed to 2,6-xylidine and which is converted to conjugation 4-hydroxy-2,6-xylidine. Not established whether the 2,6-xylidine pharmacological activity, however, the study on biological models of 2,6-xylidine potentially carcinogenic effect. Kinetic analysis revealed that the daily applications for up to one year, the maximum concentration of 2,6-xylidine of 9 ng / ml on average. anadrol for sale and its metabolites (monoetilglitsinksilidid, glitsinksilidid and 2,6-xylidine) does not accumulate in the body e, the equilibrium concentration is reached during the first four days of application. When the number of patches applied simultaneously with one to three anadrol for sale concentration in plasma slowly increases proportional relation.
anadrol for sale and its metabolites are excreted in the urine (more than 85% in the form of metabolites, less than 10% unchanged). The major metabolite in the urine – a conjugate of 4-hydroxy-2,6-xylidine of approximately 70 – 80% of the dose in urine output. The metabolite 2,6-xylidine is excreted in the urine in a concentration of less than 1% of the dose received. The half-life of anadrol for sale after dermal application of the patch is 7.6 hours. At the heart, kidney or liver failure may slow excretion of anadrol for sale and its metabolites.
Indications for use :
– neuropathic pain associated with previous herpes infection transferred (Herpes zoster), postherpetic neuralgia.
– Hypersensitivity of allergic and non-allergic genesis to the active substances and excipients of the preparation;
– hypersensitivity allergic and nonallergic origin to local anesthetics amide group (eg, bupivacaine, etidocaine, mepivacaine and prilocaine)
– inflammation or violation of integrity of the skin at the site of application patch (e.g., rashes herpes zoster, wounds or atopic dermatitis).
Use with caution in severe cardiac, renal or hepatic insufficiency (see “Special Instructions”.).
Pregnancy and lactation :
anadrol for sale crosses the placenta. Data on the use of anadrol for sale in pregnant women are not available, so during pregnancy, drug use, if the expected benefit to the mother outweighs the potential risk to the fetus.anadrol for sale is excreted in breast milk. Since anadrol for sale is metabolized relatively quickly and primarily in the liver, it can be expected that the extremely small amounts of anadrol for sale can be displayed in breast milk. Data on the use of the patch Versatis in nursing mothers is not, so during breastfeeding drug is used only if the expected benefit to the mother outweighs the potential risk to the child.
Dosage and administration :
The patch is designed for outdoor use. The patch is adhered to the skin in the area of pain once a day for a period up to 12 hours. Can be applied simultaneously to 3 plasters. If necessary, the patch can be cut into pieces before removing the plastic protective film. The patch should be adhered to intact, dry, nevospalennuyu skin (after complete healing of herpes sores) covering an area of pain.
Then remove the patch and make a break for at least 12 hours. Do not use the patch again removed.
The patch adheres to the skin immediately after removal from the sachet and removal of plastic film with an adhesive layer. The hair must be cut off with scissors (do not shave). The effectiveness of therapy is necessary to re-evaluate after 2-4 weeks of starting treatment. If the response to treatment is insufficient time or therapeutic effect is determined by only the barrier properties of the patch, the treatment should be discontinued. It is necessary to regularly assess the effectiveness of treatment to determine the optimum number of simultaneously applied plasters needed to cover the pain, or to increase the periods of time between patch applications. The use Versatis plaster under the age of 18 years is not recommended.
There is no data on the safety and efficacy of Versatis plaster in patients under the age of 18 years.
After sticking plaster to avoid hand contact with the eyes, you should wash your hands immediately.
Used patch contains active ingredient. Discard the patch immediately after use.
After removal from the skin patch to be folded in two adhesive side inward, so that the surface containing the active substance was not visible. Used patches should not be accessible to children or pets.
Adverse Reactions :
Adverse reactions were observed in approximately 16% of patients treated with Versatis. Since the drug is used topically, in most cases, adverse reactions are local and occur in the application of the patch.The most common adverse reactions are local reactions following in the area of the patch application: erythema, rash (to vesicular), pruritus, burning, dermatitis at the site of application.
The table below lists adverse reactions identified in clinical use of the drug in post-herpetic neuralgia. They are listed according to organ system and frequency of occurrence. The frequency of occurrence is defined as follows: “very often» (≥ 1/1 0), “often» (≥ 1/100 – <1/10), «rare» (≥ 1/1000 – <1/100), «rarely »(≥ 1/10000 – <1/1000),« very rare »(1/1 ≤ 0000),” insufficient evidence “(based on the impossible to estimate the frequency of available data).
|Body system||side reaction|
|Disorders of the skin and subcutaneous tissue|
|Infrequently||Losses and damage to the skin|
|General disorders and local reactions|
|Often||Reaction at the site of application|
The following adverse reactions have been reported with post-marketing use of the drug.
|Body system||side reaction|
|Violations by the immune system|
|Rarely||Anaphylactic reaction, hypersensitivity|
|General disorders and local reactions|
|Rarely||Breach of integrity of the skin|
All adverse events were mild or moderate intensity. Less than 5% of cases of adverse reactions have been a cause of discontinuation of the drug.
With the proper use of the drug development of systemic adverse events is unlikely, since the treatment of plaster containing 5% anadrol for sale, delivery of the active ingredient into the systemic circulation is insignificant (see. “Pharmacokinetics” section). Systemic adverse reactions associated with the use of anadrol for sale, identical reactions characteristic of local anesthetics of the amide group (see. “Overdose” section).
If you experience any of these side effects in the instructions, or seen any other side effects not mentioned in the instructions, inform your doctor.
An overdose of anadrol for sale in the application of the patch Versatis unlikely. An overdose can not be excluded due to incorrect use of the drug (for example, use more than 3 plasters at the same time, application of the patch for more than 12 hours or use a patch in the areas of damaged skin), in such cases, the plasma concentration of anadrol for sale may be increased. Symptoms of overdose may include: dizziness, vomiting, drowsiness, seizures, mydriasis, bradycardia, arrhythmia and shock. In case of overdose can interact with anadrol for sale p adrenoblokatorami, inhibitors of CYP3A4 isoenzyme (eg, imidazole and derivatives, macrolides) and antiarrhythmic drugs.
If you suspect an overdose, the patch must be removed from the skin and measures maintain vital body functions. Antidote to anadrol for sale not.
Interaction with other drugs :
The experiences of the drug were observed clinically significant interactions with other drugs.
Because the maximum concentration of anadrol for sale in plasma is low, the occurrence of clinically significant pharmacokinetic interaction unlikely.
Although the absorption of anadrol for sale through the skin is usually low, caution should be exercised when applying the patch I containing anadrol for sale 5% in patients receiving antiarrhythmic drugs of class I (for example, tokaini d, mexiletine) or other local anesthetic and because there is a risk of the additive system effect.
Special instructions :
The patch should not be used on mucous membranes. Avoid contact with the eye area of the patch.
The plaster contains propylene glycol which may cause skin irritation and methyl parahydroxybenzoate and propyl parahydroxybenzoate which may cause allergic reactions (possibly delayed).
Use caution when using the patch Versatis in patients with severe heart, kidney or liver failure. After first opening the sachet, the drug should be used within 14 days, opening the sachet must be kept tightly closed. The drug should not be stored in the refrigerator or freeze.
Effects on ability to drive and use machines :
As systemic absorption is minimal, there is no reason to assume the existence of influence on the ability to drive and the ability to operate machinery.
Product form :
patch. 5 patches in a sachet. 1, 2 or 6 sachets in a carton box together with instructions for use.
Store at temperatures not above 25 ° C. Do not store in the refrigerator and do not freeze. Once opened, keep the sachet tightly closed. Keep out of the reach of children. shop steroids boldenone undecylenate 300mg steroidwithdrawal.biz