Anadrol 50mg – an antiviral drug, a synthetic analogue of the acyclic purine nucleoside having a highly selective effect on herpes viruses. Inside the infected cells by viral thymidine kinase undergoes a series of successive transformation reactions of anadrol 50mg in mono -, di – and triphosphate of anadrol 50mg. anadrol 50mg triphosphate is incorporated into the viral DNA chain, and blocking its synthesis by competitive inhibition of viral DNA polymerase.In vitro anadrol 50mg effective against herpes simplex virus – Herpes simplex type I and II, against the virus Varicella zoster; higher concentrations required for inhibition of Epstein-Barr virus. In vivo anadrol 50mg is effective therapeutically and prophylactically, especially viral infections caused by Herpes simplex.

Pharmacokinetics
The ingestion bioavailability is 15-30%. anadrol 50mg well penetrates into all organs and tissues, including the brain and skin. Plasma protein binding amounts to 9-33% and is independent of its concentration in plasma. Concentration in CSF is about 50% of its concentration in plasma. anadrol 50mg crosses the placental barrier and accumulates in breast milk. The maximum concentration after administration of 200 mg inside 5 times a day – 0.7 mg / ml, the time to reach maximum kontsentratsii- 1.5-2 hours.

It is metabolized in the liver to form a pharmacologically inactive compound 9-karboksimetoksimetilguanina. The half-life in adults with normal renal function is 2-3 hours. In patients with severe renal failure half-life – 20 hours, during hemodialysis – 5.7 hours (with up to 60% of the initial value of anadrol 50mg plasma concentration decreases). About 84% excreted by the kidneys in unchanged form and 14% – in the form of metabolites. Renal clearance of aciclovir is 75-80% of the total plasmatic clearance. Less than 2% anadrol 50mg is excreted from the body through the intestines.

Indications for use
– Treatment of infections of the skin and mucous membranes caused by viruses Herpes simplex type I and II, both primary and secondary, including genital herpes.
– Prevention of relapse of relapsing infections caused by viruses Herpes simplex type I and II, in patients with normal immune status.
– Prevention of primary and recurrent infections caused by Herpes simplex virus type I and II patients with immunodeficiency.
– In the complex treatment of patients with severe immune deficiency: the HIV infection (AIDS stage, the early clinical manifestations and detailed clinical picture) and in patients undergoing bone marrow transplantation.
– The treatment of primary and recurrent infections caused by the virus Varicella zoster (chickenpox and shingles – herpes zoster).

Contraindications

 

  • Hypersensitivity to anadrol 50mg, ganciclovir, famciclovir, valanadrol 50mg, or any excipient product.
  • The drug is contraindicated during lactation.
  • Children under 3 years of age (for a given dosage form)

 

Precautions: pregnancy, the elderly and patients receiving high doses, especially against the background of dehydration, renal failure, neurological disorders, or neurological reactions to receiving cytotoxic drugs (including history).

Pregnancy and lactation.
Use during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. anadrol 50mg crosses the placental barrier and accumulates in breast milk. If you want to receive anadrol 50mg during lactation require interruption of breastfeeding.

Dosing and Administration
Inside. The drug is taken during or immediately after meals and washed down with plenty of water.

Treatment should begin as soon as possible, immediately after the first symptoms.

The dosage regimen set individually depending on the severity of the disease.

In treating infections of the skin and mucous membranes caused by Herpes simplex types I and II: Adults: drug prescribed 200 mg five times daily for 5 days with 4 hour intervals during the day and 8 hour intervals for a night. In more severe cases, the disease course of treatment can be extended by a physician up to 10 days. In the combined therapy in patients with severe immunodeficiency, including the developed clinical picture of HIV infection (including early clinical manifestations of HIV infection and AIDS stage) after implantation of bone marrow administered 400 mg 5 times a day.

For the prevention of recurrence of infections caused by Herpes simplex viruses types I and II, in patients with normal immune status and disease relapse prescribed 200 mg four times a day every 6 hours duration of the course – from 6 to 12 months.

For the prevention of infections caused by Herpes simplex viruses types I and II, immunocompromised adults, it is recommended to assign the drug at 200 mg four times a day, every 6 hours maximum dose – 400 mg anadrol 50mg five times per day depending on the severity of the infection.

Children: for the treatment of infections caused by the Herpes simplex and prophylaxis of infections in patients with weakened immune defenses, children over 3 years of age receive the same dose as adults.

In the treatment of infections caused by Varicella zoster: Adults: 800 mg 5 times a day every 4 hours during the day and 8 hour intervals for a night. Duration of treatment – 7-10 days.

Children: varicella administered 20 mg / kg 4 times a day for 5 days (maximum single dose – 800 mg) for children from 3 to 6 years: 400 mg 4 times a day, over 6 years: 800 mg 4 times a day for 5 days.

In the treatment of infections caused by Herpes zoster, adult 800 mg administered 4 times a day, every 6 hours for 5 days.

In patients with impaired renal function:
In the treatment and prevention of infections caused by Herpes simplex, in patients with creatinine clearance less than 10 ml / min, the dosage should be reduced to 200 mg 2 times a day with a 12-hour intervals.

In the treatment of infections caused by Varicella zoster, in patients with creatinine clearance less than 10 ml / min is recommended to reduce the dosage to 800 mg 2 times a day with a 12-hour intervals;with creatinine clearance of 25 mL / min is assigned to 800 mg 3 times a day at 8-hour intervals.

Side effects from the gastrointestinal tract: in rare cases – abdominal pain, nausea, vomiting, diarrhea.

Laboratory parameters: transient slight increase in liver enzymes, rarely – a small increase in levels of urea and creatinine, hyperbilirubinemia, leukopenia, erythropenia.

On the part of the central nervous system: rarely – headache, weakness; in some cases, tremor, dizziness, fatigue, exhaustion, drowsiness, insomnia, confusion, hallucinations, decreased concentration.

Allergic reactions: skin rash, itching, Lyell’s syndrome, urticaria, erythema multiforme exudative, including Stevens-Johnson syndrome, fever.

Other: rare – alopecia, peripheral edema, blurred vision, lymphadenopathy.

Overdose
Oral administration of 20 g of anadrol 50mg does not cause specific symptoms.

Can show side effects from the CNS – convulsions, tremor, lethargy. In case of overdose after ingestion it is necessary to induce vomiting (preferably within 30 minutes of ingestion) and take absorbents.

In the case of acute renal failure and anuria: maintaining vital functions, hemodialysis. Peritoneal dialysis is less effective.

Interaction with other medicinal products
Concomitant use with probenecid increases the mean half-life and reduced clearance of anadrol 50mg.

When concomitantly with nephrotoxic drugs increases the risk of renal dysfunction.

Cautions
Prolonged or repeated treatment with anadrol 50mg patients with reduced immunity could lead to the emergence of virus strains that are insensitive to its action. Apply strictly prescribed by a doctor to avoid complications.

Be wary appoint patients with impaired renal function, elderly patients due to increased half-life of anadrol 50mg. In applying the drug is necessary to ensure a sufficient amount of liquid.

When receiving the drug should monitor kidney function (blood level of urea and creatinine in blood plasma).

anadrol 50mg does not prevent the transmission of sexually transmitted herpes, so the period of treatment should refrain from sexual intercourse, even in the absence of clinical manifestations. buy legal anabolic steroids online

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