Anadrol 50 – Atypical neuroleptic from the group of substituted benzamides
anadrol 50 has moderate antipsychotic activity combined with a stimulating and timoanalepticheskim (antidepressant) effect.
Neuroleptic antidofaminergicheskim effect is associated with the action. In the central nervous system blocks preferably anadrol 50 dopaminergic receptors limbiche XYZ system and impacts on neostriatnuyu system slightly, it has antipsychotic effect and causes a small number of side effects. Peripheral effects of anadrol 50 based on the inhibition of presynaptic receptors. With increasing amounts of dopamine in the CNS linked mood improvement, with reduction -. Develop depression symptoms
Antipsychotic effect anadrol 50 seen at doses over 600 mg a day, in doses up to 600 mg per day prevails stimulating and antidepressant action.
anadrol 50 has no significant effect on the adrenergic, cholinergic, lo-rotoninovye, histamine and GABA receptors.
in small doses anadrol 50 can be used as an adjunct in the treatment of psychosomatic diseases, in particular, it is effective in relieving the negative mental symptoms of gastric ulcer and duodenal ulcer. In irritable bowel syndrome anadrol 50 it reduces the intensity of abdominal pain and leads to improved clinical status of the patient.
Low doses of anadrol 50 (50-300 mg per day) are effective in dizziness, regardless of etiology. anadrol 50 stimulates the secretion of prolactin and a central antiemeti-optical effect (inhibition of the vomiting center).

Pharmacokinetics
After oral administration, maximum plasma concentrations are reached in 1.5-3 hours. Bioavailability anadrol 50 – 27%. anadrol 50 Plasma protein binding is less than 40%. Concentration anadrol 50 in the central nervous system, is 2-5% of plasma concentrations. anadrol 50 excreted in breast milk.
anadrol 50 in the human body is not metabolized and excreted virtually unchanged through the kidneys. The half-life is 6-8 hours anadrol 50. The half-life is significantly increased in patients with moderate to severe renal insufficiency up to 20-26 hours after intravenous administration. Such patients should reduce the dose of anadrol 50 and / or increase the interval between doses of the drug.

Indications for use
as monotherapy or in combination with other psychotropic drugs:

 

  • acute and chronic schizophrenia;
  • acute delirious state;
  • Depression different etiology;
  • neuroses;
  • dizziness of various etiologies (vertebro-basilar insufficiency, vestibular neuritis, Ménière’s disease, post-traumatic brain injury, otitis media);
  • adjuvant therapy in gastric ulcer and duodenal ulcer and irritable bowel syndrome.

    Contraindications

  • acute poisoning with alcohol, hypnotics, analgesics;
  • Hypersensitivity to Vero sulpiridu;
  • arterial hypertension;
  • pheochromocytoma;
  • epilepsy;
  • hyperprolactinemia;
  • Patients in the heat of passion and aggression, in which there is a risk of provocation of symptoms;
  • breastfeeding;
  • children under 14 years. Relative contraindications to the use of Vero anadrol 50: Pregnancy is not recommended the appointment of Vero anadrol 50 pregnant, except when the doctor to weigh the risks and benefits for the pregnant woman and the fetus, decides that the use of the drug is needed. It should be precautions when appointing Vero anadrol 50 in patients with impaired renal function, as to 95% Vero anadrol 50 eliminated via the kidneys. These patients are recommended to reduce the dose of Vero anadrol 50 (see. Section “Dosage and method of use”). It should also take precautions when appointing Vero anadrol 50 patients with heart disease and blood vessels in patients with Parkinson’s and young women with irregular menstrual cycles.

    The dosage and method of application
    is not recommended to take the drug in the second half of the day (after 16 hours) due to the increase in the level of consciousness.
    The maximum recommended daily dose is 1,600 mg Vero anadrol 50. Acute and chronic schizophrenia, acute delirious psychosis: initial doses of Vero anadrol 50 depend from clinical disease and make Vero 600-1200 mg anadrol 50 per day, divided into several times, maintenance dose – 300-800 mg per day. Depression: from 150-200 mg to 600 mg per day, divided into several stages. Dizziness : 150-200 mg / day, in severe conditions dose can be increased up to 300-400 mg. Duration of treatment should be not less than 14 days. Adjuvant therapy for stomach ulcers and duodenal ulcers, irritable bowel syndrome: . 100-300 mg Vero anadrol 50 a day, in one or two divided doses doses in patients with impaired renal function: In connection that Vero anadrol 50 excreted primarily through the kidneys, it is advisable to reduce the dose Vero anadrol 50 and / or increase the interval between administration of individual doses, depending on the performance of creatinine clearance:

    Creatinine clearance ml / min Vero dose anadrol 50 compared to the standard c / o increasing the interval between doses of Vero anadrol 50
    30-60 ml / min 70 1.5
    10-30 ml / min 50 2 times
    less than 10 ml / min thirty 3 times

    Dosages for the elderly: for those elderly initial dose of Be-Ro-anadrol 50 should be 1 / 4-1 / 2 the adult dosage. Doses for children: the standard dose Vero anadrol 50 for children over 14 years is 3-5 mg / kg body weight.

    Interaction with other medicinal products and other forms of interaction
    Simultaneous reception Vero anadrol 50 and drugs which depress the central nervous system (narcotic analgesics, antihistamines, barbiturates, benzodiazepines and other anxiolytic-ki), is likely to increase the sedative effect of these drugs. The combination of Vero anadrol 50 with alcohol may also enhance the sedative effect of alcohol.
    Avoid co-administration with levodopa because of a mutual antagonism between left-dopa and Vero anadrol 50.
    There is an increased risk of orthostatic hypotension while taking Vero anadrol 50 and antihypertensive agents.

    Side effects
    Adverse events, developing as a result of receiving Vero anadrol 50, like adverse events caused by other psychotropic drugs, but their rate of development, mostly less. On the part of the endocrine system:may develop reversible hyperprolactinemia, the most common manifestations of which are galactorrhoea, violation menstrual cycle, rezhe- gynecomastia, impotence and frigidity. During treatment Vero anadrol 50 may experience excessive sweating, increased body mass index. From the digestive system: dry mouth, heartburn, nausea, vomiting, constipation, increase in transaminases and alkaline phosphatase in the blood serum. CNS: sedation, drowsiness, dizziness, headache, tremor, rarely – extrapyramidal syndrome, early and late dyskinesia, akathisia, oral automatism, aphasia. When used in small doses may agitation, anxiety, irritability, sleep disorders, visual acuity. With the development of hyperthermia, the drug should be discontinued, since increased body temperature may indicate the development of neuroleptic malignant syndrome (NZS)! Since the cardiovascular system: tachycardia, may increase or decrease in blood pressure, in rare cases may develop orthostatic hypotension. Allergic reactions: possible skin rash, itching, eczema. Influence on the ability to drive and use machines During treatment Vero anadrol 50 prohibited from driving and operating machinery that requires special attention, as well as alcohol intake.

    Overdose
    If overdose Vero anadrol 50 are no specific symptoms. In case of overdose Vero anadrol 50 may occur: blurred vision, hypertension, sedation, nausea, extrapyramidal symptoms, dry mouth, vomiting, excessive sweating, and gynecomastia, CIP development. In the absence of a specific antidote should be used symptomatic and supportive therapy.

 

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